导 师 简 介 | 陈宁，生物化学博士，东湖学者领军人才、二级教授，硕士、博士生导师，湖北省有突出贡献中青年专家；武汉体育学院博士后流动站博士后合作导师，运动训练监控湖北省重点实验室主任，天久运动营养食品研发中心主任。主要从事运动或营养干预对慢性疾病的预防与康复机理研究、细胞自噬功能状态对于运动适应、运动机能提高、肌肉质量维持、运动创伤修复等方面的探讨以及衍生性精准靶向产品的开发，同时与国内外多所知名大学、科研院所、企业建立了密切合作关系。先后就读于湖北中医药大学获药学学士学位、武汉体育学院获运动医学硕士学位、美国乔治亚州立大学获生物化学博士学位。近年来主持国家自然科学基金、湖北省创新科技团队、国家体育总局等研究项目10多项；在Journal of Cachexia Sarcopenia and Muscle, Ageing Research Reviews, Trends in Endocrinology and Metabolism, Food Science and Human Wellness, Pharmacological Research, Oncogene等国内外知名SCI杂志上发表高水平学术论文80多篇并获较高引用率 (Google Scholar Citations: 14546)，在Springer Nature出版社出版Exercise, Autophagy and Chronic Diseases英文专著1部，并于2022、2023年连续两年成功入选全球前2%顶级科学家；在国际学术会议上主持或进行科研成果交流80多次；成功申报并获批国际或中国发明专利8项；获中国体育科学学会科学技术奖二等奖1项、中国商业联合会全国服务业科技创新奖二等奖1项。现为中国生物物理学会运动与公共健康分会副会长，国家重点研发计划项目与国家自然科学基金项目等评审专家；Food Science and Human Wellness副主编，Journal of Future Foods副主编，Advanced Exercise and Health Science 执行主编。 近5年来在国际期刊上发表的部分学术论文 (*为通讯作者) 1. Mohammad Nasb, Minghui Wei, Ning Chen*. Unraveling precision exercise: A journey from efficacy to molecular insights. Advanced Exercise and Health Science. 2024, in press. 2. Minghui Wei, Tong Wu, Ning Chen*. Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease. Ageing Research Reviews. 2024, 94: 102177. (中科院一区，影响因子：13.1). 3. Mohammad Nasb, Weichu Tao, Ning Chen*. Alzheimer's disease puzzle: delving into pathogenesis hypotheses. Aging and Disease, 2024, in press. (中科院二区，影响因子：7.4). 4. Weichu Tao, Hu Zhang, Xia Jiang, Ning Chen*. Resveratrol combats chronic diseases through enhancing mitochondrial quality. Food Science and Human Wellness, 2024, 13: 597-610. (中科院一区，影响因子：7.0). 5. Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Chen*. Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease. Journal of Neuroinflammation. 2023, 20: 76. (中科院一区，影响因子: 9.587). 6. Wei Chen, Xiaoyu Cheng, Yingnan Ma, Ning Chen*. Foodborne doping and supervision in sports. Food Science and Human Wellness. 2023, 12(6): 1925-1936. (中科院一区，影响因子：8.022). 7. Wenjun Cai, Tong Wu, Ning Chen*. The amyloid-beta clearance: from molecular targets to glial and neural cells. Biomolecules. 2023, 13(2): 313. (中科院二区，影响因子：5.5). 8. Jiling Liang, Hu Zhang, Zhengzhong Zeng, Jun Lv, Jielun Huang, Xiaowen Wu, Minghui Wang, Jiahao Xu, Jingjing Fan, Ning Chen*. MicroRNA profiling of different exercise interventions for alleviating skeletal muscle atrophy in naturally aging rats. Journal of Cachexia Sarcopenia and Muscle. 2023, 14: 356-368. (中科院一区，影响因子：12.063). 9. Qiuyue Wu, Jingjing Tao, Liangwen Wu, Wei Wei, Xiping Zhang, Zhao Zhang, Xuejun Zhang, Xia Jiang, Ning Chen*. Corn peptide enhances exercise performance and prevents myocardial damage of mice caused by overtraining through activating autophagy. Journal of Functional Foods. 2022, 97: 105227. (中科院二区，影响因子：5.223). 10. Hu Zhang, Jiling Liang, Ning Chen*. The potential role of miRNA-regulated autophagy in Alzheimer's disease. International Journal of Molecular Sciences, 2022, 23: 7789. (中科院二区，影响因子：6.208). 11. Hu Zhang, Xiaowen Wu, Jiling Liang, Michael Kirberger, Ning Chen*. Irisin, an exercise-induced bioactive peptide for health promotion during aging process. Ageing Research Reviews. 2022, 80: 101680. (中科院一区，影响因子：11.788). 12. Wei Liu, Mengdie Zhao, Songming Li, Dong Uk Ahn, Ning Chen*, Xi Huang. Advances in preparation and bioactivity of phosvitin phosphopeptides. Journal of Future Foods. 2022, 2: 213-222. 13. Cenyi Wang, Jiling Liang, Baoming Jin, Yuanyuan Ren, Guodong Wang, Ning Chen*. A preclinical systematic review of the effects of chronic exercise on autophagy-related proteins in aging skeletal muscle. Frontiers in Physiology, 2022, 13: 930185. (中科院二区，影响因子：4.755) 14. Hu Zhang, Jiling Liang, Qiuyue Wu, Jinxiu Li, Ya Liu, Liangwen Wu, Jielun Huang, Xiaowen Wu, Minghui Wang, Ning Chen*. Swimming suppresses cognitive decline of HFD-induced obese mice through reversing hippocampal inflammation, insulin resistance and BDNF level. Nutrients. 2022, 14(12): 2432. (中科院二区，影响因子：6.706). 15. Hu Zhang, Ning Chen*. Adropin as an indicator of T2DM and its complications. Food Science and Human Wellness, 2022, 11: 1455-1463. (中科院一区，影响因子：8.022). 16. Liling Liang, Cenyi Wang, Hu Zhang, Jielun Huang, Juying Xie, Ning Chen*. Exercise-induced benefits for Alzheimer's disease by stimulating mitophagy and improving mitochondrial function. Frontiers in Aging Neuroscience, 2021, 13: 755665. (中科院二区，影响因子：5.702). 17. Lei Xu, Xiaoyu Zou, Zhiqiang Gao, Caifeng Mao, Hang Su, Chunyan Li, Ning Chen*. Improved fatty acid profile reduces body fat and arterial stiffness in obese adolescents upon combinatorial intervention with exercise and dietary restriction. Journal of Exercise Science & Fitness, 2021, 19(4): 234-240. 18. Jiling Liang, Hu Zhang, Zhengzhong Zeng, Liangwen Wu, Ying Zhang, Yanju Guo, Jun Lv, Cenyi Wang, Jingjing Fan, Ning Chen*. Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway. Metabolites, 2021, 11(5): 323. 19. Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, …, Ning Chen…. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2021, 17(1): 1-382. (中科院一区，影响因子：16.016). 20. Zhengzhong Zeng, Jiling Liang, Liangwen Wu, Hu Zhang, Jun Lv and Ning Chen*. Exercise-induced autophagy suppresses sarcopenia through Akt/mTOR and Akt/FoxO3a signal pathways and AMPK-mediated mitochondrial quality control. Frontiers in Physiology, 2020, 11: 583478. 21. Hu Zhang, Jiling Liang, Ning Chen*. Do not neglect the role of circadian rhythm in muscle atrophy. Ageing Research Reviews, 2020, 63: 101115. (中科院一区，影响因子：10.616). 22. Jingjing Fan, Ziyuan Feng, Ning Chen*. Spermidine as a target of cancer therapy. Pharmacological Research, 2020, 159: 104943. (中科院一区，影响因子：7.658). 23. Dandan Chen, Ying Zhang, Meng Zhang, Jingru Chang, Zhenzhong Zeng, Xianjuan Kou, Ning Chen*. Exercise attenuates brain aging by rescuing down-regulated Wnt/β-catenin signaling in aged rats. Frontiers in Aging Neuroscience, 2020, 12: 105. 24. Xianjuan Kou, Dandan Chen, Ning Chen*. The regulation of microRNAs in Alzhemier’s disease. Frontiers in Neurology, 2020, 11: 288. 25. Jiling Liang, Zhengzhong Zeng, Ying Zhang, Ning Chen*. Regulatory role of exercise-induced autophagy for sarcopenia. Experimental Gerontology, 2020, 130: 110789. 26. Klaus W. Lange, Yukiko Nakamura, Ning Chen, Jianjun Guo, Shigehiko Kanaya, Katharina M. Lange, Shiming Li. Diet and medical foods in Parkinson’s disease. Food Science and Human Wellness, 2019, 8: 83-95. 27. Qingxue Li, Shaohui Jia, Lei Xu, Biao Li, Ning Chen*. Metformin-induced autophagy and irisin improves INS-1 cell function and survival in high-glucose environment via AMPK/SIRT1/PGC-1a signal pathway. Food Science and Nutrition, 2019, 7: 1695-1703. 28. Jinfeng Xie, Jiling Liang, Ning Chen*. Autophagy-associated signal pathways of functional foods for chronic diseases. Food Science and Human Wellness, 2019, 8: 25-33. 29. Xianjuan Kou, Dandan Chen, Ning Chen*. Physical activity alleviates cognitive dysftunction of Alzheimer’s disease through regulating the mTOR signaling pathway. International Journal of Molecular Sciences, 2019, 20: 1591. 30. Biao Li, Jingjing Fan, Ning Chen*. A novel regulator of type II diabetes: microRNA-143. Trends in Endocrinology and Metabolism, 2018, 29(6): 380-388. (中科院一区，影响因子：10.893). 31. Ying Zhang, Ning Chen*. Autophagy is a promoter for exercise performance during high-altitude training. Oxidative Medicine and Cellular Longevity, 2018, 2018: 3617508. 32. Xianjuan Kou, Biao Li, Julia B Olayanju, Justin M. Drake, Ning Chen*. Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients, 2018, 10(3): 343. 33. Shufang Zhang, Ning Chen*. Regulatory role of microRNAs in muscle atrophy during exercise intervention. International Journal of Molecular Sciences, 2018, 19(2): 405. 34. Shufang Zhang, Ying Zhang, Biao Li, Ning Chen*. Physical inactivity induces the atrophy of skeletal muscle of rats through activating AMPK/FoxO3a signal pathway. European Review for Medical and Pharmacological Sciences, 2018, 22(1): 199-209. 35. Jingjing Fan, Yong Sun, Xuejiao Lin, Yixin, Xu, Lei Xu, Yan Zhao, Ning Chen*. Soluble dietary fiber enhances glucose uptake and mitigates insulin resistance in human liver cancer (HepG2) cell model via AMPK/SIRT1 signal pathway. Current Topics of Nutraceutical Research, 2018, 16(1): 75-84. 36. Lingjie Wang, Junlong Du, Furong Qin, Fangyu Zhao, Zonghai Chen, Jingru Chang, Zili Wang, Fengjie Wang, Houcong Li, Xianbing Chen, Ning Chen*. Trillium tschonoskii Maxim Saponin Mitigates D-galactose-induced Brain Aging of Rats through Rheb/mTOR Signal Pathway. Biomedicine and Pharmacotherapy, 2018, 98: 516-522. 主要招生与研究方向：运动人体科学，运动康复，特种医学 1. 运动或营养干预对慢性疾病预防与康复的机制研究与精准靶向性产品开发 2. 运动适应与机能提高、运动损伤修复的分子生物学基础与精准靶向性产品开发 3. 运动营养补剂对体能康复的机制研究与精准靶向产品开发 近年来主持省部级以上科研项目 1. 湖北省高等学校实验室工作研究会实验室研究项目，HBSY2023-028，虚拟仿真在实验室安全教育与管理中的应用研究，2023/12 – 2024/12, 主持，在研。 2. 湖北省教育厅“运动与脑科学优势特色学科群”，2021/01 – 2025/12，在研。 3. 运动干预通过miR-34a-Sirt1-FoxO信号轴调控细胞自噬改善衰老性肌萎缩的作用机制，国家自然科学基金面上项目，编号：32071176，主持，2021/01 – 2024/12，在研。 4. 运动干预对II型糖尿病的预防与治疗：运动诱导的Irisin对miR-143介导的细胞自噬功能状态在II型糖尿病中的调控作用与机制，国家自然科学基金面上项目，编号：31771318，主持，2018/01－2021/12. 5. 运动干预对衰老性肌萎缩的预防与康复：细胞自噬功能状态的关键作用与调节机制研究, 国家自然科学基金面上项目，编号：31571228，主持，2016/01－2019/12； 6. “运动干预对慢性疾病预防与康复”湖北省优秀中青年科技创新团队，项目编号：T201624，湖北省教育厅高等院校创新团队项目，主持，2017/01－2019/12； 7. 细胞自噬功能状态对运动干预衰老性肌肉萎缩的关键作用与机制，国家体育总局研究项目，编号：2014B093, 主持，2014/09－2016/08； 8. 细胞自噬对肌肉运动适应与运动能力提高的研究与机制，湖北省教育厅规划项目，编号：B2014107, 主持，2014/01－2015/12； 9. 细胞自噬是肌肉运动适应与运动能力提高的促进剂，国家体育总局重点研究领域项目，编号：2012B024，主持，2012/09－2014/08； 10. 运动协同亚精胺通过自噬功能调控对衰老性肌萎缩的预防，中国博士后基金，项目编号：2015M582292, 博士后指导老师。 |
